Prism Health North Texas

InMind: Clinical Research Spotlight

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The InMind study is evaluating treatment interventions for HIV-associated neurocognitive disorders (HAND).   HAND is a broad term that describes problems related to thinking, memory, mood and physical coordination/function.   Very often the symptoms of HAND are so mild that they go unnoticed by the patient and the provider.   However, HAND symptoms can progress to moderate or severe levels at which point it can become debilitating for the patient.    HAND is thought to be caused by HIV weakening the immune cells that protect neuron cells which make up the brain and nervous system as well as causing inflammation which also damages neurons over time.   Symptoms of HAND are quite common in their mild form and can be caused by problems other than HAND such as depression, anxiety, and alcohol and drug use.  

Symptoms of HAND include:

  • Difficulty recalling things that you’ve just read or heard
  • Slower recall of facts and memories
  • Trouble paying attention for long stretches
  • Difficulty learning new tasks
  • Feelings of sadness, hopelessness or anxiety
  • Diminished reflexes, feeling “fuzzy headed”

The purpose of the InMind study is to determine if two medications currently approved for treatment of HIV (Selzentry and Tivicay) improve neurocognitive performance and functioning in participants who have at least mild neurocognitive impairment.   Participants in this study will undergo neurocognitive testing and assessments before and after starting the medication to assess if there is improvement in neurocognitive function.

To be eligible to participate you must be:

  • Living with HIV and suppressed on antiretroviral therapy for at least 6 months prior to study entry.
  • At least mild HIV-associated neurocognitive impairment on neurocognitive tests completed at screening.
  • No past medical history of medical conditions that may cause cognitive impairment.
  • No medical history of Hepatitis C
  • No previous use of Selzentry or Tivicay.

If you are interested in participating, please contact Lauren Rogers at 972-807-7370.

 

-Written by Lauren Rogers in the winter edition of PHNTX’s LifeLines.